Background: Zearalenone (ZEA) is known as a nonsteroidal oestrogenic mycotoxin produced by different species of Fusarium fungi. ZEA is known for its competitive effects with the natural 17-β estradiol to bind with the specific binding sites of the estrogen receptors (Ers). On the other hand, the cyclin family (especially cyclin D1) and E2F1 genes are the checkpoint genes involved in cell cycle....

CDKAL1 (cyckin-dependent kinase 5 regulatory subunit-associated protein 1-like 1) has been shown to be associated with type 2 diabetes in various ethnic groups; however, contradictory results have been reported. We performed a comprehensive meta-analysis of 21 studies for rs7756992, 17 studies for rs7754840 and 10 studies for rs10946398 variants of the CDKAL1 gene to evaluate the effect of CDKA...

Let R be a prime ring with center Z, I nonzero ideal of and D: × → symmetric bi–(α, α)-derivation d the trace D. In present paper, we have considered following conditions: i) [d(x), x]α,α = 0, ii)[d(x), ⊆ Cα,α, iii)(d(x), x)α,α iv)D1(d2(x), x) v)d1(d2(x)) f(x), for all x, y ∈ I, where D1 D2 are two bi-(α, α)-derivations, d1, d2 traces D1, respectively, B: is bi-additive mapping, f B.

We report a structure-based biological approach to identify the proton-transfer pathway in photosystem II. First, molecular dynamics (MD) simulations were conducted analyze H-bond network that may serve as Grotthuss-like proton conduit. MD show D1-Asp61, acceptor of H2O at Mn4CaO5 cluster (W1), forms an via one water molecule with D1-Glu65 but not D2-Glu312. Then, D1-Glu65, D2-Glu312, and adjac...

background: esophageal squamous cell carcinoma (escc) is one of the lethal cancers with a high incidence rate in asia. many genes including cyclin d1 and p16 play important role in its carcinogenesis. we aimed to analyze the expressions of cyclin d1 and p16 with the various clinicopathological characteristics of escc.   method: we examined 30 biopsy samples of escc for cyclin d1 and p16 protein...

Objective(s): Hepatocellular carcinoma (HCC) is one of the most significant health condition around the world. As the only curative therapies, liver transplantation and surgical resection are the clinical treatments of HCC. Due to the systemic toxicity and severe side effects of these treatments, it is vital to establish new therapeutic approaches. The present study ai...